In recent years, supply chains have faced immense challenges due to geopolitical disruptions and the COVID-19 pandemic, necessitating adaptation to become more resilient. Key indicators, such as the Geopolitical Risk with Trade index and the Global Supply Chain Pressure Index, reveal heightened volatility and stress in global trade. Supply chain leaders must address critical issues like tariff changes, route blockages, material constraints, cyber threats, and labor market shifts. Emphasizing organizational readiness is vital for enhancing competitiveness, requiring leaders to optimize operations, clarify decision-making, and develop digital workflows to navigate these complexities effectively.